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Zhang Yixin

Suicide Related Gene 5HTTLPR and Gene Therapy


Abstract

With the development of society, fast-pace of life leads people to higher and higher pressure. As a result, suicide rate has increased, then how to prevent suicide has become a serious problem that we need to resolve. So far, most common way of preventing suicide is psychological counselling and medication. However, the invention of gene therapy brings a new way of preventing suicide for people. This paper aims at to find out whether the difference of genes can affect human’s exceptional behavior - suicideand to discuss whether we can change humans exceptional behavior -suicide by gene therapy. In order to illustrate these questions, four points need to be made. Firstly, introducing what is serotonin and how it works is a good beginning; whether people have exceptional behavior is due to the content of serotonin in their body. Secondly, discuss why people kill themselves from a genetic point of view. The gene - 5HTTLPR (5 - Hydroxy Tryptamine Gene-Linked Polymorphic Region) can explain this question. Finally, figure out the principle of gene therapy. These researches demonstrate that changing human’s exceptional behavior by gene therapy is possible. However, with the current level of biotechnology, there are some technical matters which we need to solve.

Movie

Suicide Related Gene 5HTTLPR and Gene Therapy.mp4


Research

•Miyakawa Tsuyoshi (2001)  Kokoro ha idenshi de dokomade kimarunoka – pasonarugenomujidai no nokagaku, Tokyo: NHK
•Ando Juko (2014) Iden to kankyo no shinrigaku ningenkodoidengaku nyumon Tokyo: Baifukan
•有田 秀穂(arita hidebo) 「セロトニン欠乏脳‐キレる脳・鬱の脳をきたえ直す」 2003年12月10日 日本放送出版協会
•鈴木 映二 「セロトニンと神経細胞・脳・薬物」 2002年11月18日 星和書店
•野島 博 (Hiroshi Nojima) 「絵でわかる遺伝子治療」(An Illustrated Guide to Gene Therapy) 2014年10月25日 講談社
•本庶 佑 「これだけは知っておきたい‐遺伝子医学の基礎’知識」 2003年7月25日 メディカルドゥ
•服部 成介 「よくわかる ゲノム医学‐ヒトゲノムの基本からテーラーメード医療まで」 2011年12月1日 羊土社
•Tom Strachan (2016) Genetics and Genomics in Medicine Tokyo: MEDSi

https://www.youtube.com/watch?v=VitFvNvRIIY
https://www.youtube.com/watch?v=znZVsNBkrQs
•http://www.vitamindinfo.co.kr/?p=3076&ckattempt=1
•http://www.saludplena.pe/los-antidepresivos-alteran-el-cerebro-en-pocas-horas/
•https://www.researchgate.net/figure/270762037_fig3_Figure-16-Serotonin-Transporter-5HTT-Gene-5HTT-functions-to-reuptake-serotonin